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KMID : 0974619980160020033
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Bulletin of Dongnam Health University
1998 Volume.16 No. 2 p.33 ~ p.45
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The Control of Catecholamine and ^(3)H-Spiperone Receptor in Rat Brain Tissues and Human Bloods
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Abstract
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In-synaptic transmission catecholamine and it´s 3H-spiperone bindings stimulate the adenylate cyclase activity which reflects the change of biological response. In rats or men medicated with the agonist to activate or the antagonist to, inactivate metabolites, the changes of catecholamine and it´s 3H-spiperone bindings in the nerve system were as follows.
1. In administrated with imipramine to affect as agonist too activate adrenergic receptor in the rats and the depression patients, the plasma concentrations of circulating catecholamine were increased.
2. In administrated with haloperidol as antagonist to : inactivate dopamine receptor" in the rats and the schizophrenic patients, the, plasma concentrations of dopamine and it s 3H-spiperone bindings were decreased.
Such results shows that the low levels of catecholamine in plasma could be increased in the treatment process of depression patients medicated with imipramine as agonist to activate metabolites, while haloperidol medication as antagonist could be reduced the levels of. dopamine in serum and it´s. 3H-spiperone receptor in the treatment process of the schizophrenic patients.
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